Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody AF2507 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemPhospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberAF2507
ApplicationsWestern Blot, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready
TargetInsulin R/IGF-I R Heterotetramer
ReactivityHuman
HostRabbit
IsotypeIgG
Quantity50 ug (also 25 ug)
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
Conjugate/TagUnconjugated
ClonalityPolyclonal
Modificationsp Tyr1136, p Tyr1163, p Tyr1135, p Tyr1162
ImmunogenPhosphopeptide containing human Insulin R Y1162/Y1163 sites
ConcentrationLYOPH
PurityImmunogen affinity purified
Brand/TrademarkR&D Systems, a Bio-Techne Brand
Antibody TypePrimary Antibodies
NCBI Full Gene Nameinsulin receptor
NCBI Gene AliasesCD220, HHF5
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

Specificity: Detects human Insulin R dually phosphorylated at Y1162 and Y1163, and human IGF-I R dually phosphorylated at Y1135 and Y1136

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Phospholipid exchange shows insulin receptor activity is supported by both the propensity to form wide bilayers and ordered raft domainsJournal of Biological ChemistrySeptember 1, 2021Pavana Suresh, W. Todd Miller, Erwin Londonautoradiographic film (Bioexcell). Primary antibodies used were Anti-pYpY1162/1163 IR (Catalog number AF2507, R&D systems Inc), anti-insulin receptor β (Catalog number 3025, Cell signaling technology), and anti-phosphotyrosine

(2) Synthesis, Characterization, and In Vitro Insulin-Mimetic Activity Evaluation of Valine Schiff Base Coordination Compounds of Oxidovanadium(V)BiomedicinesMay 17, 2021Turtoi M, Anghelache M, Patrascu AA, Maxim C, Manduteanu I, Calin M, Popescu DL.rabbit anti-phosphorylated INS R-Y1162/3 (pINS R, 1:400, R&D Systems, Minneapolis, MN, USA cat. No. AF2507) and mouse anti-β-actin (1/2000, Bio-Rad cat. no. MCA5775GA). After washing, the membrane was exposed

(3) A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell lineInternational journal of oncologyOctober 1, 2014Benabbou N, Mirshahi P, Bordu C, Faussat AM, Tang R, Therwath A, Soria J, Marie JP, Mirshahi M.

(4) Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myelomaThe Journal of biological chemistryNovember 30, 2012Purushothaman A, Babitz SK, Sanderson RD.

(5) Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signalingThe Journal of biological chemistryOctober 7, 2011Iozzo RV, Buraschi S, Genua M, Xu SQ, Solomides CC, Peiper SC, Gomella LG, Owens RC, Morrione A.

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Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody

Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody

Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody

Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody

Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody

Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (5)

Reviews

Phospho-(Insulin R Y1162/1163, IGF-I R Y1135/1136) Cross-reactive Antibody from R&D Systems, a Bio-Techne Brand

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